PY - 2010/4/1. Y1 - 2010/4/1. N2 - Objective: The APOE epsilon-4 allele has consistently emerged as a susceptibility factor for Alzheimer's disease (AD). Pro-inflammatory cytokines are detectable at abnormal levels in AD, and are thought to play a pathophysiological role.

Projekt: Omi/HtrA2 serine protease in CSF, Implication for a new biomarker profile of dementia: the role of apolipoprotein epsilon 4 allele and psysical exercise

We found that the frequency of the apoE epsilon 4 allele was 0.45 in 93 Alzheimer's disease patients, 0.46 in 23 vascular dementia patients, 0.31 in 13 dementia of the The APOE epsilon 4 allele is associated with cognitive decline and the development of dementia in the general population as well as in patients with TBI. These findings raise the question of whether patients with TBI who are APOE epsilon 4 allele carriers are more vulnerable to the negative effects of sleep apnea on their cognitive functioning. Abstract. Apoliprotein E, type {epsilon}4 allele (ApoE-{epsilon}4) is associated with late-onset sporadic Alzheimer`s disease (AD). We have found that the cumulative probability of remaining unaffected over time decreases for each dose of ApoE-{epsilon}4 in sporadic, late-onset French AD. Many clinical and basic studies have confirmed an association between the apolipoprotein E (apoE) epsilon 4 allele and the development of Alzheimer's disease (AD). Corder et al. [1] reported that survival from onset was unrelated to epsilon 4 gene dose.

Neurodegeneration : a journal for neurodegenerative disorders, … Several case-control studies have reported an association between schizophrenia and the epsilon 4 allele of Apolipoprotein E gene. The results have been equivocal. This meta-analysis has evaluated the collective evidence for an association between the e4 allele of Apolipoprotein E gene and schizophrenia. Apolipoprotein epsilon-4 allele and the two-year progression of cognitive function in Chinese subjects with late-onset Alzheimer's disease Recent observations provide evidence that the epsilon 4 allele of the apolipoprotein E gene (APOE), located in this region, is a risk factor for late-onset AD. Within this region, other genes possibly involved in the pathophysiology of AD and in strong linkage disequilibrium with the APOE locus may be responsible for this association.

There are at least three slightly different versions (alleles) of the APOE gene. The major alleles are called e2, e3, and e4. The most common allele is e3, which is

Neurology. 1995; 45: 2203-2206. View in Article.

Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: the Suita Study. Katsuya T(1), Baba S, Ishikawa K, Mannami T, Fu Y, Inamoto N, Asai T, Fukuda M, Higaki J, Ogata J, Ogihara T.

Wattmo Mellan aren 1973 till 2011 provtogs var-gar for blod och vavnad varav 23 stud.epsilon.slu.se Hereditary Blindness in a Captive Wolf (Canis lupus) Population: Frequency Reduction of a Deleterious Allele in Relation to Gene Conservation. levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype. APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.

To test the hypothesis that late-onset familial AD may represent the clustering of spor …. Apolipoprotein E, type epsilon 4 allele (APOE OBJECTIVES: The apolipoprotein epsilon 4 allele (APOE/epsilon 4) increases plasma cholesterol level and the risk for the late onset type of Alzheimer's disease. However, the correlation between hypertension and APOE/epsilon 4 has not yet been clarified. The apolipoprotein E (APOE) epsilon 4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions. OBJECTIVE: To examine the association of epsilon 4 with decline in different cognitive systems. DESIGN: Longitudinal cohort study.
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E epsilon4 Allele Is. Associated with Increased Atrophy in Progressive Mild Cognitive Impairment: A Allele variation in loci for adaptive response in Bulgarian wheat cultivars and landraces and its effect on variation in lycopene epsilon cyclase tapped for maize.

Association of APOE ε4 allele with LOAD … Sadigh-Eteghad et al. Abstract.
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Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer’s Disease Patients Carrying the APOE Epsilon 4 Allele Alen Zollo , 1 , 2 Zoe Allen , 3 Helle F. Rasmussen , 1 Filomena Iannuzzi , 1 Yichen Shi , 3 Agnete Larsen , 1 Thorsten J. Maier , 1 , 4 and Carmela Matrone 1

We have found that the cumulative probability of remaining unaffected over time decreases for each dose of ApoE-{epsilon}4 in sporadic, late-onset French AD. Apoliprotein E, type {epsilon}4 allele (ApoE-{epsilon}4) is associated with late-onset sporadic Alzheimer`s disease (AD). We have found that the cumulative probability of remaining unaffected over time decreases for each dose of ApoE-{epsilon}4 in sporadic, late-onset French AD. The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Apolipoprotein E epsilon 4 and catechol-O-methyltransferase alleles in autopsy-proven Parkinson's disease: Relationship to dementia and hallucinations August 2005 Movement Disorders 20(8):989 - 994 Object: In this paper we tested the hypothesis if patients with severe traumatic brain injury and presence of the apolipoprotein E (APOE) epsilon 4 allele are more prone to undergo the surgical pro The frequency of the apo epsilon 4 allele (0.37), which confers dose-dependent susceptibility to atherosclerosis and AD in Caucasians, was twice as high, and apo E4 homozygotes were 3-5 fold more 2021-03-22 · @article{Martinoli1995AssociationOA, title={Association of apolipoprotein epsilon 4 allele and neuropathologic findings in patients with dementia.}, author={M.

Nucleic acids research

Object: In this paper we tested the hypothesis if patients with severe traumatic brain injury and presence of the apolipoprotein E (APOE) epsilon 4 allele are more prone to undergo the surgical pro

The APOE epsilon 4 allele is associated with cognitive decline and the development of dementia in the general population as well as in patients with TBI. These findings raise the question of whether patients with TBI who are APOE epsilon 4 allele carriers are more vulnerable to the negative effects of sleep apnea on their cognitive functioning. As we did observe a possible additive interaction between the APOE ε4 allele and low physical activity for AD risk, APOE ε4 carriers may particularly benefit from an active lifestyle. Although we did not find a gene–environment interaction for general dementia risk, a protective effect of physical activity on the risk for dementia was found in both APOE ε 4 allele carriers and non-carriers. Results: The presence of at least one epsilon 4 allele was associated with faster cognitive decline in the incident population-based AD group (p = 0.01). Parallel results were produced for the two prevalent dementia samples only when adjusting for disease severity or excluding the most impaired participants from the analyses.

E4-allelen medför en förhöjd risk att utveckla Alzheimers sjukdom, ca 3-4 gånger högre risk för heterozygota anlagsbärare och upp till ca 10

In particular, the APOE*4 allele is a risk factor for susceptibility to coronary artery protein E epsilon 4 and Alzheimer's disease in elderly.

Inheritance of a specific apo epsilon allele (apo epsilon 4) determines in part the risk and the mean age at onset of Alzheimer's disease. ApoE has been found to bind isoform specifically to beta-amyloid protein, the Abstract. Apoliprotein E, type {epsilon}4 allele (ApoE-{epsilon}4) is associated with late-onset sporadic Alzheimer`s disease (AD). We have found that the cumulative probability of remaining unaffected over time decreases for each dose of ApoE-{epsilon}4 in sporadic, late-onset French AD. Apoliprotein E, type {epsilon}4 allele (ApoE-{epsilon}4) is associated with late-onset sporadic Alzheimer`s disease (AD). We have found that the cumulative probability of remaining unaffected over time decreases for each dose of ApoE-{epsilon}4 in sporadic, late-onset French AD. The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD).